Stan: Perhaps I could just start by discussing this issue about the fracture line. I'd advise everybody to forget about the fracture line immediately. It's an artificial line drawn in by the manufacturers of machines and it's a line drawn through an area of about 20% below average bone density of a young population. If you start talking about fracture lines people immediately imagine that they're going to fracture and that's really not the case at all. The bone density is merely an estimate of fracture risk, it's not all or nothing. So if your bone density happens to be slightly low it merely means that your risk of fracturing is greater than normal. It doesn't mean that you're on a fracture line, or you will or you won't fracture. Coming to Aredia, this is a drug which belongs to a class of drugs called biphosphonates and most people will know the flagship of that class by the name of Fosamax. Now these drugs started life as pyrophosphates in washing detergents, and the manufacturers of washing detergents noted that washing machines with pyrophosphates didn't get deposits of calcium in them. And that's the birth of this class of drugs, and that was many years ago in the 1960s. They've changed now to a different class of phosphates - the biphosphonates. Aredia is very similar to Fosamax, and it belongs to nitrogen-containing drugs with biphosphonate. So there's Aredia and Fosamax and another one which will be released next year. In general, biphosphonates are very good for osteoporosis. Now once again, when we talk about being good for osteoporosis we talk about preventing fractures. As long as a drug will prevent fractures, it is good for osteoporosis. The only problem with Aredia is that unlike Fosamax, hormone therapy and other drugs for osteoporosis it has never been proven in clinical trials to stop fracture. We assume it works, but it's not proven and therefore we really limit it to people who are unable to take Fosamax or any other drugs for osteoporosis.

Win: Calcium Sandos Forte - is that the best calcium to take?

Stan: They are all really very much the same. What I suggest you do is look on the bottle of calcium and on the bottle of any reasonable calcium it will tell you the amount of elemental calcium. If the elemental calcium says 500mg per tablet, bearing in mind that you need 1000mg per day and you need to take two tablets, that should be fine. Whichever brand you choose is completely immaterial because they all work very well.

Win: Thank you very much.