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Today, 24 November 2009

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Question

I was diagnosed as having Gilbert's Syndrome 5 years ago. Please could you give me information on treatment and the progress of this condition. I am concerned as my general health seems to be getting worse.

Answer

Gilbert's Syndrome is a benign condition which is one of the hereditary unconjugated hyperbilirubinaemias. This is due to a defect in the liver enzyme glucuronyl transferase. To try and put this into English - bilirubin is one of the substances in the liver which is a biproduct of the metabolism of haemoglobin (the molecule which carries oxygen in the blood). The yellow colour of jaundice seen in the skin and the whites of the eyes is caused by increased levels of bilirubin in the blood. This can be a result of a number of conditions such as hepatitis, or a defect in liver enzymes such as glucuronyle transferase. This particular enzyme is the one which breaks down the bilirubin in the blood, allowing it to be excreted through the faeces. If there is not enough of the glucuronyl transferase, as in Gilbert's Syndrome, then the levels of bilirubin in the blood will increase.

Gilbert's Syndrome is a fairly common condition, requiring no treatment as it is not dangerous. If your health is deteriorating, then you should consult your GP, or physician, as it is unlikely to be due to Gilbert's Syndrome.

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